Day 2 :
The University of Toledo, USA
Time : 10:00-10:30
Mohamed Samir Hefzy is currently serving as Associate Dean of Graduate Studies and Research Administration of the College of Engineering and Professor of Mechanical, Industrial and Manufacturing Engineering at The University of Toledo (UT), Toledo, Ohio. He has been on the faculty of The UT since 1987. He graduated from Cairo University, Egypt, with a BE in Civil Engineering in 1972, and a BSc in Mathematics from Ain-Shams University in 1974. He earned his MS in Aerospace Engineering in 1977 and his PhD in Applied Mechanics in 1981, both from The University of Cincinnati. He then received training as a Postdoctoral Research Associate for two years in the Department of Orthopedic Surgery at The University of Cincinnati’s College of Medicine. In December 2003, he was elevated to the Grade of American Society of Mechanical Engineers (ASME) Fellow. He is the recipient of many awards, including the 2011 Distinguished Service Award from the ASME.
It has been reported that by 2030, total knee arthoplasties are expected to grow to 3.48 million procedures as younger; more active patients can be treated with TKR’s surgical interventions. The success of this procedure is determined by the quality in its outcome. Young and active patients are expected to perform activities that require the knee to be maximally flexed. It is thus very important to fully determine the knee behavior when it is maximally flexed. The primary aim of this study was to determine the contact characteristics at the tibio-femoral (TF) and patella-femoral (PF) joint during deep knee flexion. A3-D finite element model of the human knee joint was developed using ABAQUS. Our results show that the PF contact occurs at the patellar groove on the femoral condylar surface at 900 of knee flexion and the contact location shifts distally along the groove on the femoral condyles as knee flexion increases. The PF contact was primarily located at the proximal half of the patellar articular surface. The TF contact initially occurs near the center of tibial plateau and then moves posteriorly towards the edge of the tibial plateau as the knee flexion angle increases. In deep knee flexion, the TF contact mainly occurs at the posterior edge of the tibial plateau. The results also show that lift-off occurs during deep squat, as the medial condyle lifts away from the tibia. The results of this study can be used to design a better TKR that better reproduces normal knee characteristics.
Pennsylvania State University,USA
Time : 10:30-11:00
Dr. Wang got his B.S. degree in Environmental Chemistry at Jilin University in 1995. He switched the major to Chemical Engineering and got his M.S. degree in 1998 from Dalian Institute of Chemical Physics, the Chinese Academy of Sciences under the supervision of Prof. Xiaojun Ma. He pursued his Ph.D. education in Biomedical Engineering at Duke University between 2000 and 2004, studying drug and gene delivery with Drs. Fan Yuan and Chuan-Yuan Li. Afterwards, Dr. Wang worked with Drs. Bruce Sullenger and Eli Gilboa at Duke University Medical Center before taking a faculty position at the University of Connecticut in August 2006. He received a CAREER Award and a CREATIV Award from NSF in 2010 and 2012, respectively. Dr. Wang was promoted to associate professor (with tenure) in August 2011 and he moved from UConn to Penn State in January 2013 (with tenure).
Human tissues are materials responsive to mechanical and chemical stimuli for a diverse array of functionalities. We have been developing tissue-mimicking materials that can respond to numerous biological and physical stimuli. This presentation will introduce how to develop programmable aptamer-functionalized hydrogels and how the functionalities of these hydrogels are specifically regulated with high fidelity at the DNA and protein levels. Our data have shown that aptamers could be effectively incorporated into hydrogels and that the incorporation ofaptamers into hydrogels did not compromise the capability of aptamers in recognizing target molecules and the mechanical properties of the hydrogels. Importantly, the incorporated aptamerswere able to hold protein drugs with high binding strength and specificity. By rationally designing aptamer sequences, different release kinetics could be achieved. We believe that these programmable hydrogels hold great potential for a variety of biomedical applications ranging from drug delivery to regenerative medicine.