2^nd International Conference and Expo on Biomechanics and Implant Design November 07-08, 2016 Las Vegas, Nevada, USA

Zodwa Dlamini is Deputy Vice Chancellor; Research, Innovation & Engagements at Mangosuthu University of Technology and a Professor of Molecular and Functional Genomics. She was previously Deputy Executive Dean at UNISA. She is also the current Vice-Chairperson of the South African Medical Research Council

Board. She completed her BSc and BSc Hons. in Biochemistry at University of Western Cape, MSc at University of Natal and PhD at University of Natal. Her research interests include the “Omics technologies including the use of bioinformatics to provide unprecedented possibilities to identify the underlying molecular

basis of cancer”.

RBBP6 is an alternately spliced gene that gives rise to three unique splice variants with diverse biological functions. Its gene products have been demonstrated to play a role in cell cycle regulation, apoptosis and protein processing. RBBP6 homologues have been shown to be negative regulators of the guardian of cells, p53, linking it to tumourigenesis. We have shown that it is involved in lung carcinogenesis. We have also shown that RBBP6 isoform 3 is a regulator of G2/M cell cycle arrest. We aimed to explore the function of RBBP6 isoform 3 and its expression pattern in carcinogenesis. Cell cycle arresting agents, such as arsenic trioxide and cisplatin were used to arrest colon and cervical cells to study the role of the smallest RBBP6 isoform. The expression and cell distribution of RBBP6 were analysed using real-time PCR and western blotting and cell analysis flow cytometry, respectively. We used immunohistochemistry to establish the expression patterns of RBBP6 in colon and cervical cancer tissues. RBBP6 isoform 3 causes cell cycle arrest at G2/M and its diminished expression results in cell cycle progression. We have also shown that RBBP6 isoform 3 plays a role in cell cycle regulation and carcinogenesis in cervical and colon tissues. These studies have shown that RBBP6 isoform 3 has great potential as a therapeutic target for drug development.

Petr Sifta completed PhD from Faculty of Physical Education and Sport, Charles University in Prague and Post-graduate in Biomechanics during 2002-2005 and working in External cooperation with Technical University in Liberec, Faculty of mechanical engineering from 2008. He is a member of Czech Society of Kinesiology from 2008

Recovery of muscle in athletes is often discussed topic in sport training. There is a great need to decrease the muscle tone in order to recover the muscle tissue. The most used techniques to improve recovery are massage, various techniques of stretching, cryotherapy, active recovery (light exercise), warm, sauna, hydrotherapy, food supplements, dry needling etc. The aim of the research is to find a method that speeds up a recovery of muscle tissue (in terms of rheology, viscosity and elasticity) and to prove, if the recovery of muscle tissue after applied aerobic exercise may be helped by any technics. Objective of the research is to evaluate and compare four types of recovery and find out which method is most efficient to improve recovery of triceps surae muscle after aerobic exercise. We suppose that muscle recovery can be represented by state of viscoelastic properties of muscle (stiffness and elasticity). We use myotonometry in order to measure the muscle tone before and after used special recovery technique.